Empowering Regulatory T Cells in Autoimmunity
نویسندگان
چکیده
منابع مشابه
Role of regulatory T-cells in autoimmunity.
There has been considerable historical interest in the concept of a specialist T-cell subset which suppresses over-zealous or inappropriate T-cell responses. However, it was not until the discovery that CD4(+)CD25(+) T-cells had suppressive capabilities both in vitro and in vivo that this concept regained credibility and developed into one of the most active research areas in immunology today. ...
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CD4(+)T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity. Tfh cell differentiation depends on various factors including cell-surface molecule interactions, extracellular cytokines and multip...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2016
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2016.07.003